This is a page attempting to evaluate if there is clear evidence of a
1,25D problem with those who supplied information to marshallprotocol.com. The
answer is no there is no clear data or pattern: the intentional creation
of a general vitamin D deficiency (43% have 1,25D levels below the reference
chart) renders any interpretation suspect. > 90%
appear to be Vitamin D deficient (below the optimal range when
assays error risk is included).
- Vitamin 25D and 1,25D changes by age and not in the same proportions.
- The "D-Ratio" would need to be age based.
- The numbers below are likely biased with under/number reporting of those
with a D-Ratio under 1.25.
- The numbers are really not comparable unless done by the same laboratory
- 1,25D and 25D from the different labs on the same sample may differ
in D-Ratios due to differences in methodologies for calculating 1,25D
- D-Ratio and the normal ranges for a D-Ratio, must be obtained from
the specific lab. They alone can calculated the real probability (from
samples of the normal population). They are invalid otherwise.
- Examine all reported lab results on
MarshallProtocol was recommended.
- Tabulate the reported values where the values were available
- Plotted the values and then show the normal ranges reported
- Note: Many people intentionally placed themselves into
vitamin D deficiency prior to testing. There is no literature on how
1,25D and 25D changes in this case. There is no "normal population" to
compare the results to.
| ||From "Vitamin D status: effects on parathyroid hormone and 1,25-dihydroxyvitamin D in postmenopausal women" Am J Clin Nutr 2000;71:1577–81.
| || |
- There is a group (28%) where 1,25D exceeds 140 pmol/L
or 53 pg/ml that follows the pattern seen with sarcoidosis outlier
- Cause of this group may be the infections involved.
- The other 72% are scattered all over the place, with a lot having very
low 1,25D not seen in the sarcoidosis charts or reference charts (43% are
"off the scale" with too low 1,25D)
- There is no general pattern of a high ratio compare to the normal
- Vitamin D: Average: 67 nmol/L MATCHES GENERAL POPULATION
- Active Vitamin D (1,25D): Average:112 pmol/L MATCHES GENERAL
The distribution is shown below, very linear across the majority of values
with ~8% not.
Less linear, with significant numbers showing Vitamin D deficiencies.
||The bottom of the optimal range for Vitamin D is 78. The
suggested minimum for CFIDS
patients is 108.
Approximately 90% of the people reporting on
MarshallProtocol.com appear to be Vitamin D deficient.
Vitamin D Prospective Studies
Original 2001 WebSite as PDF for download