TH1/TH2
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Testing TH1 or TH2 dominance usually has no treatment significance unless you are doing an experimental treatment that is designed for one of the other dominance [Example, MarshallProtocol.com}. In this case, where the intent of the treatment is to shift between these two, being dominant in one and shifting more towards this will cause your immune system to be further out of wack and likely make you more vulnerable to some other illness.

A good description (With lots of pictures!!) is at:

• http://microvet.arizona.edu/Courses/MIC205/Ch17Specific%20Def/CellularImmunology.html

Remember - there can be three states:

• Balanced (includes moderate shifts)
• Strong TH1 Dominance
• Strong TH2 Dominance

Measure	TH1 Dominance	TH2 Dominance
IL2	High	Low
IL4	Low	High
IL12	High	Low
IFN-	High	Low

References:

• http://www.bloodjournal.org/cgi/content/full/89/11/4100

Caution:

"Unfortunately, the methods they use to measure intracellular cytokines are fraught with technical problems of such magnitude that they are suitable for research only and are not suitable for clinical diagnostic applications. Should any reader feel inclined, contacting any manufacturer of any of the monoclonal antibodies (e.g. Becton Dickinson/ Pharmingen) used in the assay to identify the cytokines will provide clear confirmation of this."

Labs

The following are labs identified on the internet as offering Th1/Th2 panels. We are neutral for recommendations.

• Immunosciences Lab., Inc.
  • http://www.immuno-sci-lab.com/table_41.html
• Roswell Park Cancer Institute Laboratory of Flow Cytometry
  • http://www.rpciflowcytometry.com/assays.html
• Biognost BVBA,Belgium
  • http://www.biognost.be/research/specials.asp?section=specials&taal=EN
• Pediatric General Clinical Research Center, University of Colorado Health Sciences Center and The Children’s Hospital, Denver, Colorado
  • http://www.thechildrenshospital.org/publications/crc/2-4.pdf
• Some Infertility labs may also offer testing [more info].

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