Vitamin D is sometimes viewed as a non-issue for CFIDS except when following a
protocol like that at marshallprotocol.com.
It is my opinion that Vitamin D is an important adjunct for recovery from
CFIDS (regardless of protocol). Boron may be an
assistant to Vitamin D.
I believe that Dr. Mercola, MD recommended optimal levels for Vitamin D is
- 45-50 ng/ml or 115-128 nmol/l [source]
The following table indicates how much supplementation is needed (over a 6
month period) to reach these levels.
Daily IUs of D
14 nmol/l = 1371 IU
I would recommend keeping at 4000 IU/day (FDA deems that to be
completely safe) instead of going to higher level -- and take a longer time to
One International Unit (IU) of vitamin D is defined as the activity
of 0.025 μg of cholecalciferol.
- 1 μg vitamin D = 40 units vitamin D
- 1unit vitamin D = 0.025 μg vitamin D.
Vitamin D is a generic term used to describe all substances that
exhibit the biological activity of cholecalciferol. These include:
- vitamin D1 (calciferol)
- vitamin D2 (ergocalciferol)
- vitamin D3 (cholecalciferol) <--BEST
- 1 (OH)D3 (1 Hydroxycholecalciferol; alfacalcidol)
- 25(OH)D3 (25 Hydroxycholecalciferol; calcifediol)
- 1,25(OH)2D3 (1,25,
- 24,25(OH)2D3 (24,25,
Vitamin D2 is the form most commonly added to foods
and dietary supplements (estimated to be 20% as effective as D3).
Long term low vitamin 1,25D levels have significant health risks.
- 1,25(OH)2D3 treatment reduces blood pressure, plasma renin activity,
and Ang II levels in hyperparathyroidism patients
(the poor man's Benicar)
There are some studies suggesting that Vitamin D supplements may help CFS/FM
patients especially since it reduces inflammation
"1,25(OH)2D3 with anticoagulant activity may serve as adjunctive antithrombotic
For a detail summary and recommendations, click
For the most recent research, read "Vitamin
D status, 1,25-dihydroxyvitamin D3, and the immune system."
From the full text article:
- "The active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25(OH)2D3],
has been shown to inhibit the development of autoimmune diseases"
- "An additional factor that determines the effect of vitamin D status on
immune function is dietary calcium."
- "vitamin D deficiency in particular have been shown to occur among
patients with inflammatory bowel disease (IBD)"
- "the ability of 1,25(OH)2D3 to suppress the development of various
autoimmune diseases and to prolong allograft survival, 1,25(OH)2D3 has been
called an immunosuppressive hormone"
- "dietary calcium dependent and -independent effects of 1,25(OH)2D3 on
autoimmune responses. Both dietary calcium and 1,25(OH)2D3 are important
regulators of autoimmune responses in the gastrointestinal tract and central
A recent article (Jan, 2005) in the Times (UK) is also worth reading. [quoted].
survey article on Vitamin D
D is a major controller of the entire
immune system. Depressing vitamin D will turn down (or off) the
immune system so you immune-response symptoms may disappear
-- however, it also means that the infections that you have will
no longer be fought and will rapidly reproduce. The reports of a
strong herx reaction from 1 mg of minocycline after reducing vitamin D
(when 200mg produced no herx before) appears to because of this
rapid unhindered growth of the infections. This turning off
of the immune system does not apply to just bacteria sensitive to
minocycline, but across the board to other infections: cancer virii,
viral etc. Suppress vitamin D levels have cause diabetes to appear in
test animals while their match sibling with adequate vitamin D never
The chart below shows the actual distribution of types of Vitamin D in one
group of women
From "Vitamin D status: effects on parathyroid hormone and
1,25-dihydroxyvitamin D in postmenopausal women" Am J Clin Nutr
A measure called "D-Ratio" has been proposed but never validated against real
data. The chart below shows the ratio on this typical population. Originally a
ratio of 4.0 was deemed significant
it is now down to 2.25,
or a large percentage of any population. Charting the normal range on the
you see that only about 1/3 of the patients are outside of the normal band and
may benefit from reduction of Vitamin 1,25D.
||Distribution for a normal healthy population.
REINHOLD VIETH, YASMIN LADAK, AND PAUL G. WALFISH
Age-Related Changes in the 25-Hydroxyvitamin D Versus
Parathyroid Hormone Relationship Suggest a Different
Reason Why Older Adults Require More Vitamin D
J Clin Endocrinol Metab, January 2003, 88(1):185–191
CFS/FM Literature on Vitamin D
- Low levels are seen with fibromyalgia
- Dr. Teitelbaum in Townsend Letter, "Vitamin D deficiency has also been
implicated in CFS "
- Suggested as benefiting CFS patients
Symptoms of Vitamin D Deficiency
- Weak Muscles
- Pains in legs and muscles
- Hearing Loss
- Muscle spasms caused by a low calcium level
- Weight gain / Obesity (may be acting thru reduction of
- Aggravation of the symptoms of inflammatory bowel
Health Risk of low Vitamin D (especially 1,25D)
Original 2001 WebSite as PDF for download