Sulfonamides
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Sulfa drugs or Sulfonamides (like Bactrim) are felt to be inappropriate antibiotics because they are ineffective against Cell Wall Deficient organisms (CWD) that are common with CFS.

  • ""As would be predicted by the lack of a cell wall, none of the beta lactams are effective in vitro or in vivo against M pneumoniae and neither are the sulfonamides or trimethoprim. "
     

 Long Term Impacts

  • may exacerbate lupus often co-current with CFS
  • Decreases or interferes with B-Vitamins
  • thyroid malignancy
  • Glucose-6-phosphate dehydrogenase (G6PD) deficiency (hemolytic anemia may occur in G6PD-deficient patients
  • Hepatic function impairment
  • Porphyria (sulfonamides may precipitate an acute attack of porphyria) - often co-current with CFS
     

Reference

  • Long list of drug interactions
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