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Statins (3-hydroxy-3-methylglutaryl coenyzme A reductase inhibitors or
HMG-CoA) are cholesterol reducing drugs which has also been found to affect
coagulation and is anti-inflammatory .
"Statins are also considered to have anti-inflammatory, immunomodulating and
antioxidant properties."
Benefits
- depressed blood clotting, leading to reduced rates of
prothrombin activation,
FVa generation, fibrinogen cleavage, FXIII
activation, and an increased rate of FVa inactivation.
- pro-fibrinolytic/antithrombotic effects
- an additional therapeutic tool in APS.
- 'Calming' the lining of blood vessels
(Hughes Syndrome)
- Researchers have found that it helps reduces markers of microinflammation
- Reduces inflammation in combination with angiotensin II inhibitors
Risks
- mild gastrointestinal symptoms ( < 3%)
- Reduces CoQ10 levels
- CoQ10 should be taken with Statins.
Source
See
Note: Nystatin is NOT a coenyzme A reductase inhibitors.
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