Olmesartan is an angiotensin II inhibitor antihypertensives that is
www.marshallprotocol.com . Olmesartan has more
than a 12,500-fold greater affinity for the AT1 receptor than for the AT2
main impact for CFIDS is its impact on inflammation.
Telmisartan appears to be a better choice
for CFIDS than Olmesartan.
advocates dosages higher than the FDA maximum
recommendation. Other drugs in this family
have been reported as effective below
their FDA maximum
recommendation. There is no FDA data on the risks of long term high dosage
Benicar. There are long term studies suggesting
that it may trigger life threatening Addison Disease.
Benicar does not cross the blood-brain barrier.
CFIDS cognitive issues may persist while physical energy increases
- reduction of inflammatory cytokines
- Researchers have found that its affect on microinflammation is enhanced if given with statins
- losartan (same family) with statins
reduces inflammation in combination
"combined therapy may reduce insulin resistance by multiple
mechanisms such as lipoprotein changes and reduced oxidant stress
that also contribute to NO bioavailability. "
- BENICARHCT(Sankyo Pharma)
is the trade name for
Olmesartan combines with hydrochlorothiazide.
C22, C23, C25 on back of pill (see
- without hydrochlorothiazide.
C12,C14,C15 on back of pill (see
- OPENVAS (Pfizer) is the trade name for
Olmesartan without hydrochlorothiazide.
Same Family of Drugs
Other drugs that are angiotensin II inhibitors/blockers in the same family
(note the "sartan") - often they are prescribed with Hydrochlorothiazide
or includes it:
- losartan (Cozaar) - Weight gain reported
- irbesartan (Avapro)
- candesartan - Weight gain reported
Differences occurs between these drugs with inflammation
Many CFIDS patients report 5-10
lbs per month weight gain on this medicine. This is a
common problem with Antihypertensive Medications
. It has been suggested that it
may be a result of:
- reduction in basal metabolic rate,
- reduction in the thermogenic response to meals,
- increased insulin resistance, and
- inhibition of lipolysis.
Irbesartan - "weight ... showed trends for improvement"
The hydrochlorothiazide may be the cause of the weight gain
if BenicarHCT is being used.
Hydrochlorothiazide is known to increase aldosterone
Aldosterone is known to cause weight gain.
Many CFIDS people are reported to have aldosterone deficiency
hence this increase in aldosterone has this abnormal weight gain as a
- Decreased Calcium Levels -- see
CALCIUM for detail discussion
- Adipocyte hormones adiponectin and resistin are inversely related to obesity
(less you have, the more obese).
An alternative explanation is that if not sufficient water is taken
each day, the body is unable to eliminate the wastes in the urine and is forced
to store the wastes in fat. [
Some people on Marshall protocol report kidney pain if they do not drink enough
water]. The literature report the following recommendations for normal healthy
, because of increase urine
production - a higher quality is suggested. (The use of bottled water makes
tracking the actual amount easier).
||Daily Average for Healthy
||Suggested on Benicar
||2.7 liters (91 oz)
||3.7 liters (125 oz)
The following risks are reported by