Aspirin
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Acetylsalicylic acid or aspirn or ASA is the active ingredient of salicin from white willow bark (Salix alba) which has been synthetically created. If you are doing any anticoagulants (herbs or prescription), please check with your MD before using aspirin.

EARLY in my recovery taking 650mg (2 @ 325mg) of Aspirin with every meal for 10 days (maximum dosage cited on the bottle) produced a major jump of energy about day 6. I took it in the hope that it would impact coagulation, and ascribed the energy to reduce coagulation alone -- in hind sight, it may also have worked against infections.

Benefits

  • Antibiotic effect on some infections associated with CFIDS
    "Aspirin, its metabolite salicylic acid, and 2 other unrelated NF- > kB  inhibitors showed a strong concentration-dependent inhibitory effect on chlamydial growth, indicated by the reduction of bacterial  inclusions and the titer of infectious progeny."
    "The presented results show that aspirin at concentrations as low  as 1024 mol/L markedly decreased chlamydial growth. These findings may be of pharmacological relevance in vivo, inasmuch as serum  concentrations of 10-4 to 10-5 mol/L are commonly achieved by  therapeutic doses of aspirin in humans."[full text of article]
  • anti-platelet activity [anticoagulant]
  • protect against glutamate neurotoxicity. Aspirin protects cells against ... inflammatory responses and neurodegeneration.
  • "Its main physiological effect is inhibiting prostanoid synthesis.  the high clinical effectiveness of aspirin as an anti-inflammatory, antipyretic, and analgesic drug.  Aspirin shows a variety of pharmacological activities, including:
    •  reduction of ATP storage pools,
    • increased extracellular adenosine,
    • lowered inducible nitric oxide synthase activity,
    • modulation of mitogen-activated protein kinases, and
    • the expression of a plethora of genes induced under conditions of cell stress via the regulation of transcription factor NFkappaB activity"
  • Reduces or prevents the side-effects of niacin
  • "In brain tissue subjected to hypoxia, ASA reduced oxidative stress and iNOS activity (all increased by hypoxia), but only when used at higher concentrations."

Risks

  • Vitamin E potentiates the antiplatelet effect.
  • Contains salicylates. Some people are sensitive to salicylates. For one person's experience see
  • anaphyllactic reaction 
  • risk of bleeding peptic ulcer
  • used with caution, if at all, in somebody prone to heartburn or indigestion
  • Not for use for those under 12 years of age (Reyes Syndrome Risk ) 
  • Risk increase with  H. pylori infection NOTE: H. pylori can cause APS/coagulation and thus CFIDS.

Suggestion:

  • If you have had no problems with aspirin, you may wish to try the above experiment on your self. Some people who have tried it report feeling a bit sick on the first few days (? herx ?). Check the current labeling on the aspirin bottle and keep to the recommendation on maximum dosage.
    • 0.5mg /kg(2.2lbs) is cited in some studies for long term use.
    • dosages > 100 mg/day have moderate risk of stomach problems (especially if alcohol is consumed)
    • Never exceed a dose of 1g (3 tablets) 4 times a day (4g daily total) except on doctor's advice
  • enteric coated tablets should be avoided because of the risk on very poor absorption seen in some populations. CFIDS people history of mal-absorption may be an important factor.

Reference:

Source

  • Your local grocery store or pharmacy.

See

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