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Question:  Would it be dangerous to take 2000IU continuously, without a blood test?
Answer: Finnish studies gave 2000 IU continuously to 1 year old infants  without apparent blood tests or adverse effects. The current literature suggests that up to 4000 IU of vitamin D continuously should not have significant risks if you are taking Vitamin A, Magnesium and Calcium with it.

Question:  I have thin blood as opposed to thick.  I generally need to take vitamin k to keep my chronic nose bleeds under control.  If I take bromelain or tumeric, I get recurring nose bleeds that take a really long time to stop.
Answer: One risk of long term coagulation activation is Disseminated Intravascular Coagulation (DIC). In this case, the continuous activation of coagulation has resulted in some coagulation components becoming exhausted. The first step would be to identify what component(s) have become exhausted? Is it Vitamin K? It is possible to be both a hemophilic (bleeder) and have coagulation problems - the coagulation cascade is long and problems can occur at different locations. You are the second person that I know of that bleed easily with bromelain or turmeric. Until you know exactly why you bleed so easily (and can correct it) -- avoid all of the enzymes. You may wish to proceed to infection testing and treatment before doing the enzymes.

Question: What do you suggest for HHV-6 and Ciguatera ( or other neurotoxins)? Have you had any luck with natural antibiotics?
Answer: Transfer Factor appears to work (at least for EBV) and would be suggested after any herxing from Whey ceases or becomes mild [mainly because the Transfer Factor is a lot more expensive]. There are general Transfer Factors (cheapest) and targeted Transfer Factor (can be expensive). For Ciguatera, the best chances are generic transfer factor, collustrum and olive leaf (protease inhibitor -- slows or stops reproduction). The other option is to see if you can get someone to develop a Ciguatera transfer factor. Concerning the Salt/Vitamin C protocol -- I see no problem doing that at the same time, I just do not think that it will have a high probably of success.

Note: At one time, custom transfer factor was very easy to get -- some of your blood would be injected in a pregnant cow. The cow would develop antibodies for all of your infections which will then be in the milk (especially the first milk) that the cow gave. Such milk would not be pasteurized nor heated (so that the complex molecules are not destroyed). Most of us do not have access to cows for such to occur :-( .

 Question: Should I take the Vitamin D once a day or spread out across the day?
Answer: Our goal is to get the immune system running smoothly and not to turn it off and on like a strobe light. The brand we used (not an endorsement) is Citracal which is 25D which has a half-life of weeks -- so once a day would appear acceptable, but spread out across the day may be easier. There is a theoretical question: If the new Vitamin D is immediately used by the immune system when presented (which may account for the increase of body temperature), then the "half-life" may be only 5 hrs because the 25D form of the vitamin is immediately converted to 1,25D (active form) when has a serum half-life of 5-8 hrs only. If you notice a response (for example, temp increase) that lasts 4-8 hrs then spread them out evenly as much as possible. You can find 1000 IU and 5000 IU vitamin D supplements at health food stores.

Another brand Rocaltrol (which is a 1,25D supplement) has a serum half-life of 5-8 hrs.

 

Question: I am currently using ImmunoPro. Do I need to stop it first and then add it in later?
Answer: No, the sequence given was based on trying to get the lowest possible costs overall without giving up hope-for effectiveness. Vitamins are the cheapest cost usually, then a non-denatured Whey (ImmunoPro), then bromelain. For antibiotics, tetracyclines are often the cheapest to patients and suggested to be used first. Financial constraints are a major factor for people with these illnesses -- my goal was to keep cost and risks as low as possible without loosing effectiveness.

Question: What is the odds of recovering from CFIDS with this protocol?
Answer
: In 1999, when I was looking for treatment, I found that the literature from Jadin and from Berg, indicates that their protocols had a 60+% or greater chance of full recovery. I fully recovered, as did one of my daughters. The population used to get those numbers (Arizona, South Africa) had much more sun (and thus higher Vitamin D levels) than the Pacific Northwest. Seeing 50% recovery of 4 people is in agreement with those odds.  I believe that since this Protocol uses both Berg and Jadin's approaches that the odds are likely 80% or more, but until someone does a properly constructed study -- that is speculation.

Question: My vitamin 1,25D level is 125 pmol/L or 71 mg/Ml and I have been told that this is very high. Can I take vitamin D supplements?
Answer: If you look at the chart below, you will see that 125 is the average value of these healthy people when D is 20, 80,90. The chart suggests that as you increase your D, your 1,25 will decrease and then increase again. Unless you are around 200pmol/L, you are not high. Whoever told you that it is high appears to be very wrong.

From "Vitamin D status: effects on parathyroid hormone and 1,25-dihydroxyvitamin D in postmenopausal women"  Am J Clin Nutr 2000;71:157781.

Question: My doctor says that my reading of 50 nmol/l is just a bit low but not deficient according to Merck[62-100 nmol/l) and feels that there is no need to increase it. Can you explain to me why it should be higher?
Answer: The chart below shows that in 2003 Nutritionists do not believe that you get 100% of normal function until you hit 100 nmol/l as shown in the chart below. We believe that getting up to 100% function may push many people across the line into recovery. There is up to a 38% variation in readings between labs [citation], so we would love to see a level of 138 nmol/l to make sure that you are at 100%.

 

From: Vitamin D in preventive medicine: are we ignoring the evidence? Armin Zittermann, British Journal of Nutrition (0007-1145) Volume 89(5), May 2003, pp 552-572 [This links to the complete article that you can print off for your MD]. Another article has the same conclusions : Heaney RP. Functional indices of vitamin D status and ramifications of vitamin D deficiency. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1706S-9S. The numbers in Merck are based on levels needed to see Ricketts develop.

Question: Do you have any financial interest in any of the supplements, suppliers or laboratories?
Answer
: None. I have owned stock in Dr.Reddy, an Indian Pharmaceutical Company but currently do not.

Question: Is this your protocol?
Answer
: Definitely not, I have just sorted out issues between several protocols to make them compatible and hopefully complimentary. Dave Berg and Dr. Jadin did the major work. There have been several studies showing that Vitamin D can put autoimmune diseases into remissions. The use of Anti-Inflammatory is also common practice -- and Trevor Marshall popularized the use of ARBs (there has been much research in Europe on using ARB for a variety of diseases with inflammation - he was simply the first popular preacher in the US).

Question: Why is it called Zero-Based or FWIW?
Answer: It signifies that it is starting on a clean sheet of paper -- a fresh start. In one sense it is saying that it is targeted for those who have not become hyper-medicated for a wide variety of symptoms. It may work for such individuals also -- it is simply that I have no direct experience seeing how the various stages impacts such individuals. In the case of the first two, who were Electrician Protocol Survivors [EPS], there was a need to hit the emergency brakes and take them back to square one before doing anything else -- there were lots of side-effects during, and nasty side-effects from withdrawal. Before going anywhere -- there was a need to get them back to "Zero" before starting a fresh on a different path. Hence Zero Based.

The "FWIW" came from a post on I&I by some one trying Vitamin D -- it is a pragmatic description of the protocol.

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