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Dosing Protocols
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The following protocols appear to be equivalent under the following assumptions

  • They have the maximum levels of ARBs that do not exceed the FDA recommendations
  • The concentration will stay between 63% and 100% (Numbers should be verified by your pharmacist).
  • There is no need to split pills.
  • Note: that the dosage for Valsartan is higher than those reported effective in the Marshall's article
    "Valsartan Dosing Regime Modulates Psychotic Events in Two Sarcoidosis Patients"

ARB

FDA Maximum Dosage

Half Life

Peak Concentration

Proposed Dosing

Tablet Sizes

Losartan[1]

100 mg

6-9 hrs

3-4 hrs

25 mg x 4 hrs = 100mg

25 mg

Olmesartan [2]

40 mg

13 hrs

1-2 hrs

10 mg x 6 hrs = 40mg

5mg, 20mg, 40mg

Valsartan [3]

320 mg

6 hrs

2-4 hrs

80mg x 6-8 hrs=240-320mg

80mg, 160mg

Irbesartan [4]

300 mg

11-15 hrs

1.5-2 hrs

75mg x 6-8 hrs = 225-300mg

75mg, 150mg, 300mg

Candesartan [5]

32 mg

9 hrs

3-4 hrs

4mg x 4 hrs, 8-12 mg at bedtime( 8hrs before next) = 32 mg

4mg, 8mg, 16mg, 32mg

Telmisartan[6]

80 mg

24 hrs

0.5-1 hr

40mg x 12 hrs = 80mg

40mg, 80mg

Eprosartan[7]

800 mg

5-9 hrs

1-2 hrs

 Requires tablet splitting  

400mg, 600mg

 


 

 

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