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Aldosterone is often low with CFIDS. This is an essential part of the adrenal function. Care should be taken when taking Benicar and other ARBs that are known to decrease Aldersterone to have Aldersterone tested prior to treatment and while on treatment. For a model explaining this see Hypoadrenal page.

  • Aldosterone influences the Potassium Balance (High Aldosterone --> High Potassium)


Terms: dehydroepiandrosterone (DHEA) and its sulphate derivative (DHEA-S)

Case Studies of Aldosterone and various diseases

  • "Friedman (Los Angeles CA) concluded that CFS patients in his study had defects in the renin-aldosterone axis" AACFS 6th INTERNATIONAL CONFERENCE, Virginia, 2003
  • "The hyperadrenergic subgroup of OI is characterized by a clinical spectrum including attenuated plasma renin activity and aldosterone,..."
  • "Patients with ALS, fibromyalgia, and chronic fatigue syndrome often have hypothalamic dysfunction which may result in adrenal insufficiency, hypothyroidism, and gonadal failure."
  • "CFS subjects present heterogeneous group. In some subjects cortisol response is preserved, while in the others it is similar to one found in secondary adrenal insufficiency."
  • HPA changes do not occur early in CFS, but appears late.
  • "showed impaired HPA axis function in CFS."
  • "The right and left adrenal gland bodies were reduced by over 50% in the CFS subjects indicative of significant adrenal atrophy in a group of CFS patients with abnormal endocrine parameters"
  • " DHEA and DHEA-S levels were significantly lower in the CFS compared to the healthy group"
  • 45% of CFIDS patients with orthostatic hypotension had "an abnormal renin-angiotensin-aldosterone system "
  • 50% had hyperaldosteronism, "CFS symptoms may be ameliorated by aldosterone"


    "The role of aldosterone in metabolism is the control of sodium and potassium. Regulating sodium ion concentration, in turn regulates fluid volume. Aldosterone acts to decrease excretion of sodium and increase the excretion of potassium at the kidney, sweat glands, and salivary glands. Aldosterone also conserves sodium in the colon. In each of these tissues, aldosterone works through binding at the mineralocorticoid receptors, and primarily at the cortical collecting ducts of the kidney. Regulation of sodium and potassium balance is accomplished through a complex set of hormones acting in several feedback loops. The renin-angiotensin system (RAS) is the most important negative feedback loop for volume regulation. The RAS operates through a long feedback loop (involving changes in fluid volume) and a short feedback loop (with direct inhibition of renin secretion by angiotensin II). The other feedback loop that acts simultaneously is the control of serum potassium. These interacting feedback loops act in concert to set aldosterone concentrations to maintain homeostasis for volume, blood pressure, and potassium in response to external stimuli."




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