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Marshall Protocol Risks
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The following risks are believed to exist from doing the for persons with Chronic Fatigue Syndrome, Lyme, Gulf War Illness / Sickness [GWI / GWS], Fibromyalgia [FM],  Irritable Bowel Disease [IBS IBD], Irritable Gut Syndrome [IGS] . This list is based on literature found on the National Institute of Health web site compared to an individual doing the FWIW protocol for mal-absorption illnesses such as those listed above. A person doing the may not have any of them occurring (just like George Burns had no illnesses associated with tobacco after almost 90 years of use).

  • Major risk of Addison Syndrome (5%-25% of CFS that complete the protocol)
  • Increased risk (100 300%) of Heart Attack
  • Increased risk (100+%) of Cancer (Breast, Colon and Prostate are well documented)
  • Increased risk (67+%) of Multiple Sclerosis
  • Increased risk (400+%) of Diabetes
  • Increased risk of Depression
  • Increased risk (500+%) of Osteoarthritis and Osteoporosis
  • Increased risk of nephrotic syndrome, schizophrenia and severe bipolar disorder.
  • Increased risk of Hyperparathyroidism
  • Increased risk of Crohn Disease and Sjogren's syndrome
  • Increased risk of Rheumatoid Arthritis
  • Increased risk of Systemic Lupus Erythematosus
  • May cause fetal and neonatal morbidity and death
  • Risk of Angioedema

NEW: Questions from a MPer and answers...

Trevor Marshall on Risks:

A report of an  investigator on Trevor Marshall

[Click here - we are not responisbile for content]

Dr Cheney, MD, writes:

"I'm concerned that an ARB (Angiotensin Receptor  Blocker) is being used in CFIDS patients [via] without an awareness of its effect on "Q."

Big issue [with]! If you block AT1 with an ARB [like Benicar], down will go your Aldosterone, and down will go your blood volume, and you could be in a heap of trouble [i.e. Addison Syndrome]. ARBs that bind to AT1 will constrict blood volume [which is unhealthy with PWCs].

I'm also concerned that the other receptor [AT2] is being ignored. No one knows what it does. Not even Merck! I suspect that it has an immune effect. An ARB like Benicar selectively binds very tightly to AT1, resulting in a two—to three-fold increase of Angiotensin II, which then binds to the wide-open AT2 receptor. And who knows what kind of immune responses that is setting off. This is just speculation, but I am concerned [over the safe use of Benicar for CFS].

"I don't believe that you can block a regulatory pathway [with Benicar],..... you[] have no idea what that thing is doing and then hope that down the road everything will be rosy." 

What Medical Studies says about Vitamin D

"neither increased exposure to sunlight nor increased oral intake of
vitamin D raised blood concentrations of 1,25(OH)2D " (3 studies

"as a person becomes vitamin D-deficient, there is an increase in the
concentration of parathyroid hormone (PTH), which increases the renal
production of 1,25(OH)2D, the circulating concentrations of which
often become normal or even elevated "

From: Vitamin D: importance in the prevention of cancers, type 1
diabetes, heart disease, and osteoporosis
, American Journal of
Clinical Nutrition, Vol. 79, No. 3, 362-371, March 2004 The full text
is available at:

What should your vitamin 25D reading be?

"Your vitamin D level should NEVER be below 32 ng/ml. Any levels below 20 ng/ml are considered serious defiency states and will increase your risk of breast and prostate cancer and autoimmune diseases like MS and rheumatoid arthritis.

  • Optimal 25-hydroxyvitamin D values are:

    45-50 ng/ml or 115-128 nmol/l"

Dr Joseph Mercola, MD Feb 23, 2002

The following table indicates the approximate supplementation is needed (over a 6 month period) to reach these levels. After 6 months (or more often), retest and adjustment is recommended.

Daily IUs of D Your Level
128 nmol/l
of 25D
50 ng/ml
11281 13 5
10028 26 10
8774 38 15
7521 51 20
6267 64 25
5014 77 30
3760 90 35
2507 102 40
1253 115 45
0 128 50
Based on [source] 14 nmol/l = 1371 IU

Lancet. 1989 Nov 18;2(8673):1176-8. Serum 25-hydroxyvitamin D and colon cancer: eight-year prospective study.

"Risk of getting colon cancer decreased three-fold in people with a serum 25-OHD concentration of 20 ng/ml or more."




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